Protein ADP-ribosylation is essential for the regulation of several cellular pathways,
enabling dynamic responses to diverse pathophysiological conditions. It is modulated …

Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

Effective maintenance and stability of our genomes is essential for normal cell division,
tissue homeostasis, and cellular and organismal fitness. The processes of chromosome …

DNA damage response (DDR) relies on swift and accurate signaling to rapidly identify DNA
lesions and initiate repair. A critical DDR signaling and regulatory molecule is the …

Genetic factors underlying leukocyte telomere length (LTL) may provide insights into
telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of …

Simple Summary Poly (ADP-ribose) polymerase (PARP) proteins regulate DNA damage
correction, replication, and gene transcription. By controlling pivotal aspects of these …

Reactive oxygen species (ROS) inflict multiple types of lesions in DNA, threatening genomic
integrity. How cells respond to ROS-induced DNA damage at telomeres is still largely …

Protecting telomere from the DNA damage response is essential to avoid the entry into
cellular senescence and organismal aging. The progressive telomere DNA shortening in …

ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the
dynamic interplay between its writers, readers and erasers. As an intricate and versatile …

The ADP-ribose transferase (ART) family comprises 17 enzymes that catalyze mono-or poly-
ADP-ribosylation, a post-translational modification of proteins. Present in all subcellular …