Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

Although genetic factors contribute to almost half of all cases of deafness, treatment options
for genetic deafness are limited,,,,. We developed a genome-editing approach to target a …

The proteins that form the permeation pathway of mechanosensory transduction channels in
inner-ear hair cells have not been definitively identified. Genetic, anatomical, and …

Adeno-associated virus (AAV) vectors have shown promising results in preclinical models,
but the genomic consequences of transduction with AAV vectors encoding CRISPR-Cas …

Since most dominant human mutations are single nucleotide substitutions,, we explored
gene editing strategies to disrupt dominant mutations efficiently and selectively without …

Sensory transduction in auditory and vestibular hair cells requires expression of
transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is …

Genetic hearing loss accounts for up to 50% of prelingual deafness worldwide, yet there are
no biologic treatments currently available. To investigate gene therapy as a potential …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Inner ear hair cells convert the mechanical stimuli of sound, gravity, and head movement
into electrical signals. This mechanotransduction process is initiated by opening of cation …