OBJECTIVES: The lack of cure with medical therapy implies life-long treatment emphasising
the need for a thorough understanding of the long-term outcome. We review the natural …

OBJECTIVES: Both normal and pathological growth of the prostate is dependent on
dihydrotestosterone (DHT) synthesis, which is catalysed by two 5α-reductase (5αR) …

Importance There is evidence that 5α-reductase inhibitors (5-ARIs), a standard treatment of
benign prostate hyperplasia, are associated with a decrease in the incidence of prostate …

Abstract Background The Prostate Cancer Prevention Trial (PCPT) demonstrated a 24.8%
reduction in the 7-year prevalence of prostate cancer among patients treated with finasteride …

Active surveillance is now an accepted management strategy for men with low-risk localized
prostate cancer, in recognition of the knowledge that the majority of men with such cancers …

Dutasteride (Avodart®), an oral synthetic 4-azasteroid, is a potent, selective, irreversible
inhibitor of type 1 and type 2 5α-reductase (5AR), the enzyme that converts testosterone to …

Normal growth and function of the prostate are contingent on the reduction of testosterone to
dihydrotestosterone (DHT) by 5-alpha reductase (5-AR) enzymes types 1 and 2. It has been …

Ethnopharmacological relevance Croton membranaceus leaf extracts are used in the
Bahamas to aromatize tobacco. In Nigeria it is used to improve digestion and in Ghana, the …

PURPOSE: In the prostate testosterone is converted to dihydrotestosterone by 5α-reductase
type 1 and/or 2. Although 5α-reductase type 2 is predominant in normal prostates, type 1 is …

BACKGROUND Although finasteride is recognized for its role as a chemopreventive agent
for prostate cancer, higher grades of malignancy have been reported. It is questioned …