The crucial role of CD4+ and CD8+ T cells in shaping and controlling immune responses
during immune disease and cancer development has been well established and used to …

Abstract TCRαβ+ CD3+ CD4− CD8−“double negative”(DN) T cells comprise a small subset
of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and …

Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is
increasingly recognized that this intimal inflammation is paralleled over time by a distinct …

Immune checkpoint inhibitors are a powerful new tool in the treatment of cancer, with
prolonged responses in multiple diseases, including hematologic malignancies, such as …

By producing various cytokines, expanded DNT cells in inflamed tissues contribute to the
pathogenesis of a variety of autoimmune inflammatory diseases. However, it is unclear …

T lymphocytes bearing the αβ T cell receptor (TCR) but lacking CD4, CD8, and markers of
natural killer (NK) cell differentiation are known as 'double-negative'(DN) T cells and have …

Double‐negative (DN) T cells are present at relatively low frequencies in human peripheral
blood, and are characterized as expressing the alpha‐beta or gamma‐delta T‐cell receptor …

Increased levels of naturally occurring regulatory T cells (TReg cells) have been found in a
variety of solid tumours and haematological malignancies. In multiple myeloma (MM) …

Several types of regulatory T cells maintain self-tolerance and control excessive immune
responses to foreign antigens. The major regulatory T subsets described over the past …

T lymphocytes are established mediators of ischemia reperfusion (IR)–induced AKI, but
traditional immune principles do not explain their mechanism of early action in the absence …