Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

There is a clear and unmet clinical need for biomarkers to predict responsiveness to
chemotherapy for cancer. We developed an in vitro test based on patient-derived tumor …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Biomarkers currently play an important role in the detection and management of patients
with several different types of gastrointestinal cancer, especially colorectal, gastric, gastro …

DNA methylation patterns are altered in numerous diseases and often correlate with
clinically relevant information such as disease subtypes, prognosis and drug response. With …