Regulation of MHC class II gene expression by the class II transactivator

W Reith, S LeibundGut-Landmann… - Nature Reviews …, 2005 - nature.com
MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

[PDF][PDF] Molecular and cellular interactions of HIV-1/HTLV coinfection and impact on AIDS progression

C Casoli, E Pilotti, U Bertazzoni - Aids Rev, 2007 - academia.edu
In the last 10 years HIV-1/human T-cell leukemia virus (HIV-1/HTLV) coinfection has
emerged as a worldwide health problem. The numbers of HIV-1/HTLV-1 coinfections in …

Novel role of MHC class II transactivator in hepatitis B virus replication and viral counteraction

M Dezhbord, SH Kim, S Park, N Kim… - Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Background/Aims The major histocompatibility class II (MHC II) transactivator, known as
CIITA, is induced by Interferon gamma (IFN-γ) and plays a well-established role in regulating …

A 10-amino acid domain within human T-cell leukemia virus type 1 and type 2 tax protein sequences is responsible for their divergent subcellular distribution

L Meertens, S Chevalier, R Weil, A Gessain… - Journal of Biological …, 2004 - ASBMB
Human T-cell leukemia virus type 1 and type 2 (HTLV-1/2) are related retroviruses that infect
T-lymphocytes. Whereas HTLV-1 infection can cause leukemia, HTLV-2 has not been …

The major histocompatibility complex class II transactivator CIITA inhibits the persistent activation of NF-κB by the human T cell lymphotropic virus type 1 Tax-1 …

G Forlani, R Abdallah, RS Accolla, G Tosi - Journal of Virology, 2016 - Am Soc Microbiol
Human T cell lymphotropic virus type 1 (HTLV-1) Tax-1, a key protein in HTLV-1-induced T
cell transformation, deregulates diverse cell signaling pathways. Among them, the NF-κB …

Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1

G Forlani, M Shallak, E Ramia, A Tedeschi, RS Accolla - Retrovirology, 2019 - Springer
Background Immunity against pathogens evolved through complex mechanisms that only for
sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and …

[HTML][HTML] Class II transactivator restricts viral replication, extending its effect to HBV: Editorial on “Novel role of MHC class II transactivator in hepatitis B virus replication …

CR Lee, SG Park - Clinical and Molecular Hepatology, 2024 - pmc.ncbi.nlm.nih.gov
Class II transactivator restricts viral replication, extending its effect to HBV: Editorial on “Novel
role of MHC class II transactivator in hepatitis B virus replication and viral counteraction” - PMC …

Major histocompatibility complex class II transactivator CIITA is a viral restriction factor that targets human T-cell lymphotropic virus type 1 Tax-1 function and inhibits …

G Tosi, G Forlani, V Andresen, M Turci… - Journal of …, 2011 - Am Soc Microbiol
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of an aggressive
malignancy of CD4+ T lymphocytes. Since the viral transactivator Tax-1 is a major player in …

Inhibiting Ebola virus and SARS-CoV-2 entry

AI Wells, CB Coyne - Science, 2020 - science.org
The mechanisms by which cells defend against many viruses remain largely unknown.
Defining these mechanisms is important not only for understanding viral pathogenesis but …

Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences

U Bertazzoni, M Turci, F Avesani, G Di Gennaro… - …, 2011 - pmc.ncbi.nlm.nih.gov
Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar
genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to …