Tumor immune microenvironment and genetic alterations in mesothelioma

S Hiltbrunner, L Mannarino, MB Kirschner… - Frontiers in …, 2021 - frontiersin.org
Malignant pleural mesothelioma (MPM) is a rare and fatal disease of the pleural lining. Up to
80% of the MPM cases are linked to asbestos exposure. Even though its use has been …

Emerging avenues in immunotherapy for the management of malignant pleural mesothelioma

SG Gray - BMC Pulmonary Medicine, 2021 - Springer
Background The role of immunotherapy in cancer is now well-established, and therapeutic
options such as checkpoint inhibitors are increasingly being approved in many cancers such …

Immune-related pan-cancer gene expression signatures of patient survival revealed by NanoString-based analyses

A D'Angelo, H Kilili, R Chapman, D Generali, I Tinhofer… - PloS one, 2023 - journals.plos.org
The immune system plays a central role in the onset and progression of cancer. A better
understanding of transcriptional changes in immune cell-related genes associated with …

Results of the Meso-ORIGINS feasibility study regarding collection of matched benign-mesothelioma tissue pairs by longitudinal surveillance

K Ferguson, M Neilson, R Mercer, J King, K Marshall… - BMJ open, 2023 - bmjopen.bmj.com
Objectives To assess key elements of the design for Meso-ORIGINS (Mesothelioma
Observational study of RIsk prediction and Generation of paired benign-meso tissue …

In vitro cell culture of patient derived malignant pleural and peritoneal effusions for personalised drug screening

CG Wu, F Chiovaro, A Curioni-Fontecedro… - Journal of translational …, 2020 - Springer
Background Malignant serous effusion (MSE) denotes a manifestation of metastatic disease
with typical high concentrations of both cancer and immune cells, making them an ideal …

Hormonal receptor status determines prognostic significance of FGFR2 in invasive breast carcinoma

M Braun, D Piasecka, B Tomasik, K Mieczkowski… - Cancers, 2020 - mdpi.com
Simple Summary FGFR2-ER-PR crosstalk leads to hormone-independent progression of
breast cancer. In vitro, FGFR2 stimulates PR transcriptional activity and mediates resistance …

Lung adenocarcinoma patients with malignant pleural effusions in hot adaptive immunity status have a longer overall survival

CG Wu, R Casanova, F Mairinger… - Frontiers in …, 2022 - frontiersin.org
Malignant pleural effusion (MPE) is a common complication of lung adenocarcinoma
(LADC) which is associated with a dismal prognosis. We investigated the prognostic role of …

Ancillary studies for serous fluids

L Bubendorf, P Firat, I Kulac, P Pisapia… - The International System …, 2020 - Springer
Spread of malignancies to serous cavities represents advanced stage disease that
necessitates systemic treatment. Immunochemistry (IC) is an indispensable tool to ascertain …

Evolution of mesothelioma from benign asbestos pleural inflammation

K Ferguson - 2025 - theses.gla.ac.uk
Pleural Mesothelioma (PM) is an incurable disease with a poor life expectancy. It is most
commonly associated with asbestos exposure and the latency period from exposure to PM …

Malignant Pleural Effusion: Finding Our Way Through Highly Dynamic Times

AT Woods - 2024 - search.proquest.com
Malignant pleural effusion (MPE) is a serious complication occurring when cancer cells are
found in the pleural cavity surrounding the lung. MPE is typically associated with highly …