Chikungunya fever
K Bartholomeeusen, M Daniel, DA LaBeaud… - Nature Reviews …, 2023 - nature.com
Chikungunya virus is widespread throughout the tropics, where it causes recurrent
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
outbreaks of chikungunya fever. In recent years, outbreaks have afflicted populations in East …
mRNA capping: biological functions and applications
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …
of research have established that the m7G cap serves as a unique molecular module that …
Conventional and unconventional mechanisms for capping viral mRNA
In the eukaryotic cell, capping of mRNA 5′ ends is an essential structural modification that
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …
Alphavirus RNA synthesis and non-structural protein functions
JC Rupp, KJ Sokoloski… - Journal of General …, 2015 - microbiologyresearch.org
The members of the genus Alphavirus are positive-sense RNA viruses, which are
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …
predominantly transmitted to vertebrates by a mosquito vector. Alphavirus disease in …
A structural and functional perspective of alphavirus replication and assembly
Alphaviruses are small, spherical, enveloped, positive-sense ssRNA viruses responsible for
a considerable number of human and animal diseases. Alphavirus members include …
a considerable number of human and animal diseases. Alphavirus members include …
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus
The successive emergence of highly pathogenic coronaviruses (CoVs) such as the Severe
Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory …
Acute Respiratory Syndrome (SARS-CoV) in 2003 and the Middle East Respiratory …
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase
KA Ivanov, V Thiel, JC Dobbe, Y Van Der Meer… - Journal of …, 2004 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV), a newly identified group 2
coronavirus, is the causative agent of severe acute respiratory syndrome, a life-threatening …
coronavirus, is the causative agent of severe acute respiratory syndrome, a life-threatening …
Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2′-O-methyltransferase activity
VD Menachery, BL Yount Jr, L Josset… - Journal of …, 2014 - Am Soc Microbiol
The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in
2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) …
2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) …
Self-amplifying RNA vaccine candidates: alternative platforms for mRNA vaccine development
C Schmidt, BS Schnierle - Pathogens, 2023 - mdpi.com
The present use of mRNA vaccines against COVID-19 has shown for the first time the
potential of mRNA vaccines for infectious diseases. Here we will summarize the current …
potential of mRNA vaccines for infectious diseases. Here we will summarize the current …
The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure
M Issur, BJ Geiss, I Bougie, F Picard-Jean, S Despins… - Rna, 2009 - rnajournal.cshlp.org
The 5′-end of the flavivirus genome harbors a methylated m7GpppA2′ OMe cap structure,
which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) …
which is generated by the virus-encoded RNA triphosphatase, RNA (guanine-N7) …