Dementia is one of the greatest global challenges for health and social care in the 21st
century. Alzheimer's disease (AD), the most common type of dementia, is by no means an …

The amyloid-β oligomer (AβO) hypothesis was introduced in 1998. It proposed that the brain
damage leading to Alzheimer's disease (AD) was instigated by soluble, ligand-like AβOs …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

Recent years have witnessed a revolution in our understanding of microglia biology,
including their major role in the etiology and pathogenesis of neurodegenerative diseases …

No medications prevent or reverse age-related cognitive decline. Physical activity (PA)
enhances memory in rodents, but findings are mixed in human studies. As a result, exercise …

Physical activity plays an essential role in maintaining a healthy body, yet it also provides
unique benefits for the vascular and cellular systems that sustain a healthy brain. While the …

Objective: Alzheimer's disease (AD), the most important progressive neurodegenerative
disorder, is characterized by cognitive and behavioral disabilities. Nowadays, tau, as a …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …