Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …

Both type 1 and type 2 diabetes are associated with cardiac fibrosis that may reduce
myocardial compliance, contribute to the pathogenesis of heart failure, and trigger …

In patients with diabetes, myocardial fibrosis may contribute to the pathogenesis of heart
failure and arrhythmogenesis, increasing ventricular stiffness and delaying conduction …

Diabetes is associated with increased incidence of heart failure even after controlling for
coronary artery disease and hypertension. Thus, as diabetic cardiomyopathy has become …

Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Background Obesity is a risk factor for various subtypes of cardiovascular disease (CVD),
including coronary heart disease (CHD), heart failure (HF), and stroke. Nevertheless, there …

Diabetes mellitus increases the risk of heart failure independent of co-existing hypertension
and coronary artery disease. Although several molecular mechanisms for the development …

Cardiac fibrosis is strongly associated with obesity and metabolic dysfunction and may
contribute to the increased incidence of heart failure, atrial arrhythmias, and sudden cardiac …

In patients with diabetes, an increased risk of symptomatic heart failure usually develops in
the presence of hypertension or ischemic heart disease. However, a predisposition to heart …