“NRF2 addiction” in lung cancer cells and its impact on cancer therapy
Nuclear factor erythroid 2-like factor 2 (NRF2) is a master regulator of the antioxidant
enzymes and the detoxification proteins that play major roles in redox homeostasis …
enzymes and the detoxification proteins that play major roles in redox homeostasis …
Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation
TM Penning - The Journal of steroid biochemistry and molecular …, 2011 - Elsevier
Hydroxysteroid dehydrogenases (HSDs) represent a major class of NAD (P)(H) dependent
steroid hormone oxidoreductases involved in the pre-receptor regulation of hormone action …
steroid hormone oxidoreductases involved in the pre-receptor regulation of hormone action …
Drug repositioning for Fabry disease: acetylsalicylic acid potentiates the stabilization of lysosomal alpha-galactosidase by pharmacological chaperones
Fabry disease is caused by a deficiency of lysosomal alpha galactosidase and has a very
large genotypic and phenotypic spectrum. Some patients who carry hypomorphic mutations …
large genotypic and phenotypic spectrum. Some patients who carry hypomorphic mutations …
Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs
MC Byrns, TM Penning - Chemico-biological interactions, 2009 - Elsevier
Aldo-keto reductase (AKR) 1C3 catalyzes the NADPH-dependent reduction of Δ4-
androstene-3, 17-dione to yield testosterone, reduction of estrone to yield 17β-estradiol and …
androstene-3, 17-dione to yield testosterone, reduction of estrone to yield 17β-estradiol and …
Inhibitors of aldo-keto reductases AKR1C1-AKR1C4
P Brozic, S Turk, T Lanisnik Rizner… - Current medicinal …, 2011 - ingentaconnect.com
The AKR1C aldo-keto reductases (AKR1C1-AKR1C4) are enzymes that interconvert
steroidal hormones between their active and inactive forms. In this manner, they can …
steroidal hormones between their active and inactive forms. In this manner, they can …
Cross-kingdom actions of phytohormones: a functional scaffold exploration
L Lin, RX Tan - Chemical Reviews, 2011 - ACS Publications
Plant hormones, also referred to as phytohormones, are defined to be naturally occurring
organic substances that influence at low concentrations plant physiological processes such …
organic substances that influence at low concentrations plant physiological processes such …
Spectral deciphering of the interaction between an intramolecular hydrogen bonded ESIPT drug, 3, 5-dichlorosalicylic acid, and a model transport protein
BK Paul, D Ray, N Guchhait - Physical Chemistry Chemical Physics, 2012 - pubs.rsc.org
The present work demonstrates a detailed characterization of the interaction of a bio-active
drug molecule 3, 5-dichlorosalicyclic acid (3, 5DCSA) with a model transport protein Bovine …
drug molecule 3, 5-dichlorosalicyclic acid (3, 5DCSA) with a model transport protein Bovine …
Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1)
O El-Kabbani, U Dhagat, A Hara - The Journal of steroid biochemistry and …, 2011 - Elsevier
Human 20α-hydroxysteroid dehydrogenase (AKR1C1), a member of the aldo-keto
reductase (AKR) superfamily, is one of four isoforms (with> 84% amino acid sequence …
reductase (AKR) superfamily, is one of four isoforms (with> 84% amino acid sequence …
Overview of human 20 alpha-hydroxysteroid dehydrogenase (AKR1C1): Functions, regulation, and structural insights of inhibitors
X Chu, S He, Y Liu, Y Liu, F Feng, Q Guo, L Zhao… - Chemico-Biological …, 2022 - Elsevier
Human aldo-keto reductase family 1C1 (AKR1C1) is an important enzyme involved in
human hormone metabolism, which is mainly responsible for the metabolism of …
human hormone metabolism, which is mainly responsible for the metabolism of …
Insight into the biological activity of organometallic acetylsalicylic acid (aspirin) derivatives
K Kowalski - ChemPlusChem, 2019 - Wiley Online Library
Despite of its long history as a drug, aspirin (acetylsalicylic acid, ASA) still fascinates
investigators across the fields of chemistry, biology and medicine. In this regard, the …
investigators across the fields of chemistry, biology and medicine. In this regard, the …