Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …

Lung inflammation may occur due to viral and bacterial infections, structural damage, or
inhalation of dangerous particles. These injuries may be quickly resolved by the immune …

Background Systems medicine has become a key word in biomedical research. Although it
is often referred to as P4-(predictive, preventive, personalized and participatory)-medicine, it …

Cytometric immunophenotyping is a powerful tool to discover and implement T‐cell
biomarkers of type 1 diabetes (T1D) progression and response to clinical therapy. Although …

A burn wound is a complex systemic disease at multiple levels. Current knowledge of scar
formation after burn injury has come from traditional biological and clinical studies. These …

Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among
the 10 most frequent causes of death worldwide. These infections still lack effective …

A variety of pulmonary insults can prompt the need for life-saving mechanical ventilation;
however, misuse, prolonged use, or an excessive inflammatory response, can result in …

Macrophages (Mϕs) are key players in the coordination of the lifesaving or detrimental
immune response against infections. The mechanistic understanding of the functional …

Despite the benefits of mechanical ventilators, prolonged or misuse of ventilators may lead
to ventilation-associated/ventilation-induced lung injury (VILI). Lung insults, such as …

In this paper, we combine kinetic modelling and patient gene expression data analysis to
elucidate biological mechanisms by which melanoma becomes resistant to the immune …