Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally
active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of …

Dysregulated translation is a common feature of cancer. Uncovering its governing factors
and underlying mechanism are important for cancer therapy. Here, we report that enhancer …

Autosomal-dominant spinocerebellar ataxias (SCAs) are a heterogeneous group of
neurodegenerative disorders. In this study, we performed genetic analysis of a unique form …

The nucleolus is a multifunctional nuclear domain primarily dedicated to ribosome
biogenesis. Certain viruses developed strategies to manipulate host nucleolar proteins to …

Autophagy and the ubiquitin–proteasome pathway (UPP) are the major protein degradation
systems in eukaryotic cells. Whereas the former mediate a bulk nonspecific degradation, the …

Posttranslational SUMO modification is an important mechanism of regulating protein
function, especially in the cell nucleus. The nucleolus is the subnuclear organelle …

70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control
network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4 …

Risk of relapse of endometrial cancer (EC) after surgical treatment is 13% and recurrent
disease carries a poor prognosis. Research into prognostic indicators is essential to improve …

Fibrillarin, one of the major proteins of the nucleolus, plays several essential roles in
ribosome biogenesis including pre-rRNA processing and 2′-O-ribose methylation of rRNA …

Nuclear bodies are structures in eukaryotic cells that lack a plasma membrane and are
considered protein condensates, DNA, or RNA molecules. Known nuclear bodies include …