Green synthesis and biological evaluation of 6-substituted-2-(2-hydroxy/methoxy phenyl) benzothiazole derivatives as potential antioxidant, antibacterial and …

L Racané, L Ptiček, G Fajdetić, V Tralić-Kulenović… - Bioorganic …, 2020 - Elsevier
We present a new efficient green synthetic protocol for introduction of substituents to the C-6
position of 2-arylbenzothiazole nuclei. Newly synthesized compounds were designed to …

The synthesis and structural study of two benzothiazolyl azo dyes: X-ray crystallographic and computational study of azo–hydrazone tautomerism

G Pavlović, L Racane, H Čičak, V Tralić-Kulenović - Dyes and Pigments, 2009 - Elsevier
The synthesis, FT-IR, 1H and 13C NMR characterisation, as well as crystal and molecular
structure determined by single-crystal X-ray diffraction data, of two azo dyes derived from 6 …

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose

L Racané, L Ptiček, S Kostrun… - Journal of medicinal …, 2023 - ACS Publications
We designed and synthesized a series of symmetric bis-6-amidino-benzothiazole
derivatives with aliphatic central units and evaluated their efficacy against bloodstream …

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles

L Racané, M Cindrić, I Zlatar, T Kezele… - Journal of enzyme …, 2021 - Taylor & Francis
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3, 4, 5,
6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential …

Biological activity of newly synthesized benzimidazole and benzothizole 2, 5-disubstituted furane derivatives

L Racané, I Zlatar, N Perin, M Cindrić, V Radovanović… - Molecules, 2021 - mdpi.com
Newly designed and synthesized cyano, amidino and acrylonitrile 2, 5-disubstituted furane
derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for …

Novel diamidino-substituted derivatives of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes: synthesis, antiproliferative and DNA binding properties

L Racané, V Tralic-Kulenovic… - Journal of medicinal …, 2010 - ACS Publications
A series of new diamidino-, diisopropylamidino-, and diimidazolinyl-substituted derivatives
of phenyl benzothiazolyl and dibenzothiazolyl furans and thiophenes were successfully …

New anticancer active and selective phenylene-bisbenzothiazoles: synthesis, antiproliferative evaluation and DNA binding

L Racané, SK Pavelić, R Nhili, S Depauw… - European journal of …, 2013 - Elsevier
Novel amidino-derivatives of phenylene-bisbenzothiazoles were synthesized and tested for
their antiproliferative activity against several human cancer cell lines, as well as DNA …

An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity

A Kamal, BA Kumar, P Suresh, N Shankaraiah… - Bioorganic & medicinal …, 2011 - Elsevier
An efficient one-pot iodination methodology for the synthesis of benzothiazolo-4β-anilino-
podophyllotoxin (5a–h) and benzothiazolo-4β-anilino-4-O-demethylepipodophyllotoxin (6a …

Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents

A Beč, L Racané, L Žonja, L Persoons… - RSC Medicinal …, 2023 - pubs.rsc.org
Herein we present the design and the synthesis of novel substituted coumarin–
benzimidazole/benzothiazole hybrids bearing a cyclic amidino group on the benzazole core …

Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles

L Racané, V Rep, S Kraljević Pavelić… - Journal of enzyme …, 2021 - Taylor & Francis
A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1, 2, 3-
triazole ring with ap-substituted phenyl or benzyl moiety, were synthesised and evaluated in …