Abnormal post-translational modification of microtubule-associated protein Tau (MAPT) is a
prominent pathological feature in Alzheimer's disease (AD). Previous research has focused …

Aggregates of the protein tau are proposed to drive pathogenesis in neurodegenerative
diseases. Tau can be targeted by using passively transferred antibodies (Abs), but the …

The microtubule-associated protein tau is an intrinsically disordered protein containing a few
short and transient secondary structures. Tau physiologically associates with microtubules …

Tau aggregation underlies neurodegenerative tauopathies, and transcellular propagation of
tau assemblies of unique structure, ie, strains, may underlie the diversity of these disorders …

Tau aggregation into ordered assemblies causes neurodegenerative tauopathies. We
previously reported that tau monomer exists in either inert (M i) or seed-competent (M s) …

Cryogenic electron microscopy has revealed unprecedented molecular insight into the
conformations of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It …

Abstract Background The prevalence of Alzheimer's disease, the most common type of
dementia, is continuously increasing. Many recent reports have indicated that immune …

Amyloid deposition of the microtubule-associated protein tau is associated with
neurodegenerative diseases. In frontotemporal dementia with abnormal tau (FTD-tau) …

Understanding early amyloidogenesis is key to rationally develop therapeutic strategies.
Tau protein forms well‐characterized pathological deposits but its aggregation mechanism …

Many neurodegenerative diseases, including Alzheimer's, originate from the conversion of
proteins into pathogenic conformations. The microtubule-associated protein tau converts …