The present review article offers a detailed account of the design strategies employed for the
synthesis of nitrogen-containing anticancer agents. The results of different studies describe …

Abstract Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied
compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is …

Targeting sirtuins for cancer treatment has been a topic of debate due to conflicting reports
and lack of potent and specific inhibitors. We have developed a thiomyristoyl lysine …

Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes
and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the …

Imidazole is an azole heterocycle containing two non‐adjacent nitrogen atoms added
greatly to natural products and synthetic compounds. The planar ring system associated with …

Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …

A series of heterocyclic compounds were synthesized and fully characterized. The geometry
optimization was carried out using the Density Functional Theory (DFT) method and the …

This review presents the detailed account of factors leading to cancer and design strategy
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …

Abstract Sirtuin 2 (SIRT2) is involved in a wide range of processes, from transcription to
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …