Abstract Glutathione-S-transferases (GSTs) are a family of Phase II detoxification enzymes
that catalyse the conjugation of glutathione (GSH) to a wide variety of endogenous and …

The super family of glutathione S-transferases (GSTs) is composed of multiple isozymes with
significant evidence of functional polymorphic variation. Over the last three decades, data …

The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology
is an unresolved question. Is it simply a marker of resistance to 2nd-generation androgen …

Prostate cancer is the most frequently diagnosed malignancy in American men, and a more
aggressive form of the disease is particularly prevalent among African Americans. The …

Prostate cancer remains a significant health concern for men throughout the world. Recently,
there has developed an expanding multidisciplinary body of literature suggesting a link …

PURPOSE: A new hypothesis for the etiology of prostate cancer is that chronic or recurrent
prostate inflammation may initiate and promote prostate cancer development. MATERIALS …

Candidate gene-based studies have identified a handful of aberrant CpG DNA methylation
events in prostate cancer. However, DNA methylation profiles have not been compared on a …

CpG island hypermethylation occurs in most cases of cancer, typically resulting in the
transcriptional silencing of critical cancer genes. Procainamide has been shown to inhibit …

Somatic inactivation of the glutathione S-transferase-π gene (GSTP1) via CpG island
hypermethylation occurs early during prostate carcinogenesis, present in∼ 70% of high …

Chromosomal instability appears to be key to the pathogenesis of malignant transformation
in human cancers, yet the precise molecular mechanisms underlying chromosomal …