The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus
2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan …

Currently, most vaccines available on the market are for parental use; however, this may not
be the best option on several occasions. Mucosal routes of administration such as …

Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However …

Background The sudden emergence of novel influenza viruses is a global public health
concern. Conventional influenza vaccines targeting the highly variable surface glycoproteins …

Background Recombinant adenovirus-vectored (Ad) tuberculosis (TB) vaccine platform has
demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine …

The first clinical evaluations of adenovirus (Ad)-based vectors for gene therapy were
initiated in the mid-1990s and led to great anticipation for future utility. However, excitement …

Targeting the epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKIs)
is one of the major precision medicine treatment options for lung adenocarcinoma. Due to …

A next-generation inhalable dry powder COVID vaccine Skip to main content Thank you for
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Viral vectors are a commonly used method for gene therapy because of their highly efficient
transduction of cells. However, many vectors have a small genetic capacity, and their …

Sublingual (SL) delivery, a noninvasive immunization method that bypasses the intestinal
tract for direct entry into the circulation, was evaluated with an adenovirus (Ad5)-based …