The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

The combination of transition metal catalysis and organocatalysis as a new and exciting
research area has attracted increasing attention as it can enable the development of …

In general, DA reactions can be classified into two types of suprafacial [π4s+ π2s]
cycloadditions:(i) the normal and (ii) inverse-electron-demand DA reactions (Scheme 1) …

The first catalytic asymmetric inverse‐electron‐demand (IED) oxa‐Diels–Alder reaction of
ortho‐quinone methides, generated in situ from ortho‐hydroxybenzyl alcohols, has been …

Figure 73: The proposed catalyst/substrate interaction shown in Figure 73 corresponds to
the related sulfoxidation catalyzed by chiral phosphoric acid PA 5 (ref 133). Please note that …

All domains of chemistry are increasingly impacted by organofluorine molecules, often
favorably. In asymmetric synthesis of fluorinated compounds, significant achievements are …

An inverse‐electron‐demand Diels–Alder (IEDDA) reaction could complement the
conventional normal‐electron‐demand Diels–Alder reaction in the synthesis of six …

This review is focused on the enantioselective synthesis of 3, 4-dihydropyran derivatives,
whose importance as chiral building blocks in the synthesis of bioactive molecules and …

Heterocycles are an important class of organic compounds accounting for nearly one-third of
the past decade's publications, which are in the field of heterocyclic chemistry. In fact, two …

Metal-free chiral phosphoric acids and chiral calcium phosphates both catalyze highly
enantio-and diastereoselective electrophilic α-bromination of enecarbamates to provide an …