The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

Iterative liver injury results in progressive fibrosis disrupting hepatic architecture,
regeneration potential, and liver function. Hepatic stellate cells (HSCs) are a major source of …

The promise of phenotypic screening resides in its track record of novel biology and first-in-
class therapies. However, challenges stemming from major differences between target …

Heart failure remains a major source of late morbidity and mortality after myocardial
infarction (MI). The temporospatial presence of activated fibroblasts in the injured …

Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling
process associated with different types of fibrosis. Recent studies have shown that …

The chemical diversity and known safety profiles of drugs previously tested in humans make
them a valuable set of compounds to explore potential therapeutic utility in indications …

Introduction Peyronie's disease (PD) is a debilitating affliction for the male population,
causing severe curvatures to the erect penis and erectile dysfunction in about 50% of men …

The emergence of novel SARS coronavirus 2 (SARS-CoV-2) in 2019 has triggered an
ongoing global pandemic of severe pneumonia-like disease designated as coronavirus …

Abstract Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has
been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition …

RG-7916 is a first-in-class drug candidate for the treatment of spinal muscular atrophy (SMA)
that functions by modulating pre-mRNA splicing of the SMN2 gene, resulting in a 2.5-fold …