Dynamic alterations in cellular phenotypes during cancer progression are attributed to a
phenomenon known as 'lineage plasticity'. This process is associated with therapeutic …

Over the last two decades, extra-and intracellular pH have emerged as fundamental
regulators of cell motility. Fundamental physiological and pathological processes relying on …

Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH
landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this …

Lysosomes are single membrane bounded group of acidic organelles that can be involved
in a process called lysosomal exocytosis which leads to the extracellular release of their …

Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with high
mortality due to early metastatic dissemination and high chemoresistance. All these factors …

Many tumors are characterized by marked extracellular acidosis due to increased glycolytic
metabolism, which affects gene expression and thereby tumor biological behavior. At the …

The tumor microenvironment includes diverse immune cell types immersed in a very
complex and hostile system characterized by hypoxia, nutrient deficiency and acidity …