Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to
soon be the second leading cause of cancer death. Median survival of PDA patients is 6–10 …

O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …

Aberrantly expressed onco-mucin 16 (MUC16) and its post-cleavage generated surface
tethered carboxy-terminal (MUC16-Cter) domain are strongly associated with poor …

Carbohydrates are abundantly expressed on the surface of both eukaryotic and prokaryotic
cells, often as post translational modifications of proteins. Glycoproteins are recognized by …

Simple Summary Alterations in glycosylation are frequently observed in cancer cells.
Different strategies have been proposed to increase drug delivery to the tumor site in order …

Perineural invasion (PNI) is an adverse prognostic feature of pancreatic ductal
adenocarcinoma (PDAC). However, the understanding of the interactions between tumors …

Advanced-stage solid primary tumors and metastases often express mucin 16 (MUC16),
carrying immature glycans such as the Tn antigen, resulting in specific glycoproteoforms not …

Purpose: Advances in our understanding of the contribution of aberrant glycosylation to the
pro-oncogenic signaling and metastasis of tumor cells have reinvigorated the development …

The Mucin (MUC) family, a range of highly glycosylated macromolecules, is ubiquitously
expressed in mammalian epithelial cells. Such molecules are pivotal in establishing …

Pancreatic cancer is difficult to resect due to its unique challenges, often leading to
incomplete tumor resections. Fluorescence-guided surgery (FGS), also known as …