Flavins act as a critical liaison between metabolic homeostasis and oxidative stress in the retina

T Sinha, MI Naash, MR Al-Ubaidi - Frontiers in cell and …, 2020 - frontiersin.org
Derivatives of the vitamin riboflavin, FAD and FMN, are essential cofactors in a multitude of
bio-energetic reactions, indispensable for lipid metabolism and also are requisites in …

Genome-wide association study of obstructive sleep apnea and objective sleep-related traits identifies novel risk loci in Han Chinese individuals

H Xu, F Liu, Z Li, X Li, Y Liu, N Li, X Zhang… - American Journal of …, 2022 - atsjournals.org
Rationale: Previous genetic studies of obstructive sleep apnea (OSA) have limitations in
terms of precise case definition, integrated quantitative traits, and interpretation of genetic …

Development of novel experimental models to study flavoproteome alterations in human neuromuscular diseases: the effect of Rf therapy

M Tolomeo, A Nisco, P Leone, M Barile - International Journal of …, 2020 - mdpi.com
Inborn errors of Riboflavin (Rf) transport and metabolism have been recently related to
severe human neuromuscular disorders, as resulting in profound alteration of human …

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy

A Manole, Z Jaunmuktane, I Hargreaves… - Brain, 2017 - academic.oup.com
Abstract Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor,
sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory …

MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis

Y El Morr, M Fürstenheim, M Mestdagh… - Science …, 2024 - science.org
Intestinal inflammation shifts microbiota composition and metabolism. How the host monitors
and responds to such changes remains unclear. Here, we describe a protective mechanism …

Fluoride induces immunotoxicity by regulating riboflavin transport and metabolism partly through IL-17A in the spleen

Y Qiao, Y Cui, Y Tan, C Zhuang, X Li, Y Yong… - Journal of hazardous …, 2024 - Elsevier
The impairment of the immune system by fluoride is a public health concern worldwide, yet
the underlying mechanism is unclear. Both riboflavin and IL-17A are closely related to …

Probiotic Potential of a Novel Vitamin B2-Overproducing Lactobacillus plantarum Strain, HY7715, Isolated from Kimchi

JY Kim, EJ Choi, JH Lee, MS Yoo, K Heo, JJ Shim… - Applied Sciences, 2021 - mdpi.com
Vitamin B2, also known as riboflavin, is essential for maintaining human health. The purpose
of this study was to isolate novel lactic acid bacteria that overproduce vitamin B2 and to …

Effects of a DPP4 inhibitor on progression of NASH-related HCC and the p62/Keap1/Nrf2-pentose phosphate pathway in a mouse model

T Kawaguchi, D Nakano, H Koga, T Torimura - Liver Cancer, 2019 - karger.com
Abstract Background and Aims: Diabetes mellitus is a risk factor for hepatocellular
carcinoma (HCC) in patients with nonalcoholic steatohepatitis (NASH). Dipeptidyl peptidase …

Vitamin B2 deficiency enhances the pro-inflammatory activity of adipocyte, consequences for insulin resistance and metabolic syndrome development

AI Mazur-Bialy, E Pocheć - Life sciences, 2017 - Elsevier
Aims Adipose tissue is an endocrine organ important for regulation of such physiological
processes as energy metabolism or lipids homeostasis. In an obesity state, it participates in …

Mitochondrial and peroxisomal alterations contribute to energy dysmetabolism in Riboflavin Transporter Deficiency

F Colasuonno, A Niceforo, C Marioli… - Oxidative medicine …, 2020 - Wiley Online Library
Riboflavin transporter deficiency (RTD) is a childhood‐onset neurodegenerative disorder
characterized by progressive pontobulbar palsy, sensory and motor neuron degeneration …