RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …

MicroRNAs (miRNAs) are active regulators in malignant growth and constitute potential
targets for anticancer therapy. Consequently, considerable effort has focused on identifying …

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of
RNA irreversible degradation in vivo. The most developed methods of sequence-specific …

Natural modified bases in RNA were found to be indispensable for basic biological
processes. In addition, artificial RNA modifications have been a versatile toolbox for the …

Control of the expression of oncogenic small non-coding RNAs, notably microRNAs
(miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic …

The selective degradation of disease-associated microRNA is promising for the
development of new therapeutic approaches. In this study, we engineered a series of bulge …

Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-
molecule and biologic drugs.'Smart'supramolecular assembly of catalysts offers precise …

Irreversible destruction of disease-associated regulatory RNA sequences offers exciting
opportunities for safe and powerful therapeutic interventions against human …

Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new
solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the …

Various types of acridine were conjugated to DNA and used for site-selective RNA scission
together with another unmodified DNA and a Lu (III) ion. The target phosphodiester linkage …