Ischemic stroke is a devastating brain injury resulting in high mortality and substantial loss of
function. Understanding the pathophysiology of ischemic stroke risk, mortality, and functional …

Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Substantial evidence indicates an association between clinical depression and altered
immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly …

TDP-43 (TAR DNA-binding protein 43) inclusions are a hallmark of amyotrophic lateral
sclerosis (ALS). In this study, we report that TDP-43 and nuclear factor κB (NF-κB) p65 …

Astrocytes are essential for the development and homeostatic maintenance of the central
nervous system (CNS). They are also critical players in the CNS injury response during …

Current experimental models of blast injuries used to study blast-induced neurotrauma
(BINT) vary widely, which makes the comparison of the experimental results extremely …

Cerebral stroke continues to be a major cause of death and the leading cause of long-term
disability in developed countries. Evidence reviewed here suggests that gender influences …

Alterations in neuronal connectivity, particularly in the “peri-infarct” tissue adjacent to the
region of ischemic damage, are important contributors to the spontaneous recovery of …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

The present study was designed to follow neuroinflammation after ischemic brain injury in
the long-term survival rat model. Immunohistochemistry was performed 2 years after 10 min …