p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-
associated substrate) family of adaptor proteins, which have emerged as key signalling …

This review summarises some of the knowledge we have about Crk and Grb2 family adaptor
protein signalling in health and disease and outlines the current status and the challenges …

Steroid hormones bind to their receptors and trans-activate target genes. Rapid non-
genomic action of steroid hormones has been proposed in addition to the one at the …

Advanced stages of papillary and anaplastic thyroid cancer continue to be plagued by a
dismal prognosis, which is a result of limited effective therapies for these cancers. Due to the …

Antiestrogens such as tamoxifen are widely used in the clinic to treat estrogen receptor–
positive breast tumors. Resistance to tamoxifen can occur either de novo or develop over …

Protein tyrosine phosphatase receptor T (PTPRT) is frequently mutated in a variety of human
cancers including colorectal cancer. Here we report that PTPRT knockout increases the size …

Summary The PIP 3/PI3K network is a central regulator of metabolism and is frequently
activated in cancer, commonly by loss of the PIP 3/PI (3, 4) P 2 phosphatase, PTEN. Despite …

Protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is frequently mutated in a
variety of human cancers. However, the cell signaling pathways regulated by PTPN14 …

Resistance to chemotherapy remains a major obstacle for the treatment of breast cancer.
Understanding the molecular mechanism (s) of resistance is crucial for the development of …

Adenovirus type 19 is a major cause of epidemic keratoconjunctivitis, the only ocular
adenoviral infection associated with prolonged corneal inflammation. In this study, we …