Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation
genes more than two decades ago, their protein products have been implicated in a variety …

The mammalian BTG/Tob family comprises six proteins (BTG1, BTG2/PC3/Tis21,
BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2), which regulate cell cycle progression in a …

NMDA receptors promote neuronal survival but also cause cell degeneration and neuron
loss. The mechanisms underlying these opposite effects on neuronal fate are unknown …

Epithelial cells rapidly adapt their behaviour in response to increasing tissue demands.
However, the processes that finely control these cell decisions remain largely unknown. The …

Factors that mediate p53 tumor suppressor activity remain largely unknown. In this study we
describe a systematic approach to identify downstream mediators of tumor suppressor …

Anemia suppresses liver hepcidin expression to supply adequate iron for erythropoiesis.
Erythroferrone mediates hepcidin suppression by anemia, but its mechanism of action …

While BTG2 plays an important role in cellular differentiation and cancer, its precise
molecular function remains unclear. BTG2 interacts with CAF1 deadenylase through its …

Podocyte injury plays a critical role in the progression of focal segmental glomerulosclerosis
(FSGS). Here, it is reported that B‐cell translocation gene 2 (Btg2) promotes Adriamycin …

Articular cartilage is physiologically exposed to repeated loads. The mechanical properties
of cartilage are due to its extracellular matrix, and homeostasis is maintained by the sole cell …

Abstract TIS21/BTG2/PC3, orthologs of mouse, human and rat, respectively, is initially
identified as one of the early growth response genes and induced by various stimulations …