Cardiovascular calcification heterogeneity in chronic kidney disease

JD Hutcheson, C Goettsch - Circulation research, 2023 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

Cardiovascular safety and effectiveness of bisphosphonates: from intervention trials to real-life data

C Delli Poggi, M Fusaro, MC Mereu, ML Brandi… - Nutrients, 2022 - mdpi.com
Both osteoporosis with related fragility fractures and cardiovascular diseases are rapidly
outspreading worldwide. Since they are often coexistent in elderly patients and may be …

EMbedding and backscattered scanning electron microscopy: a detailed protocol for the whole-specimen, high-resolution analysis of cardiovascular tissues

RA Mukhamadiyarov, LA Bogdanov… - Frontiers in …, 2021 - frontiersin.org
Currently, an ultrastructural analysis of cardiovascular tissues is significantly complicated.
Routine histopathological examinations and immunohistochemical staining suffer from a …

[HTML][HTML] A collagen-based laboratory model to mimic sex-specific features of calcific aortic valve disease

R Allgayer, RF Kabir, A Bergeron, P Demers… - Acta Biomaterialia, 2025 - Elsevier
Calcific aortic valve disease (CAVD) shows in the deposition of calcium phosphates in the
collagen-rich layer of the valve leaflets. This stiffens the leaflets and eventually leads to heart …

Altered Caveolin-1 Dynamics Result in Divergent Mineralization Responses in Bone and Vascular Calcification

A Bakhshian Nik, K Kaiser, P Sun… - Cellular and Molecular …, 2023 - Springer
Introduction Though vascular smooth muscle cells adopt an osteogenic phenotype during
pathological vascular calcification, clinical studies note an inverse correlation between bone …

The time-dependent role of bisphosphonates on atherosclerotic plaque calcification

A Bakhshian Nik, HH Ng, M Garcia Russo… - Journal of …, 2022 - mdpi.com
Atherosclerotic plaque calcification directly contributes to the leading cause of morbidity and
mortality by affecting plaque vulnerability and rupture risk. Small microcalcifications can …

Epidermal growth factor receptor inhibition prevents vascular calcifying extracellular vesicle biogenesis

A Bakhshian Nik, HH Ng… - American Journal …, 2023 - journals.physiology.org
Chronic kidney disease (CKD) increases the risk of cardiovascular disease, including
vascular calcification, leading to higher mortality. The release of calcifying extracellular …

CXCL4-induced PBMCs Modulate Vascular Extracellular Matrix through Wnt5a-CaMKII-dependent Release of Calcific Extracellular Vesicles and Matrix …

JB Krohn, F Sicklinger, A Spieler, S Dihlmann… - bioRxiv, 2023 - biorxiv.org
Background Macrophage heterogeneity plays an increasing role in the study of vascular
inflammatory responses. The CXCL4-induced monocyte/macrophage phenotype has …

Epidermal Growth Factor Receptor Inhibition Prevents Vascular Calcifying Extracellular Vesicle Biogenesis 2

PR Iacoviello, S Bertazzo, D Mero, BB Khomtchouk… - journals.physiology.org
The in vivo study was approved by the Institutional Animal Care and Use Committee
(IACUC) at 123 Florida International University under protocol AN20-006 and conformed to …