Metabolomics aims to measure and characterise the complex composition of metabolites in
a biological system. Metabolomics studies involve sophisticated analytical techniques such …

Epigenetic dysregulation is thought to contribute to the etiology of schizophrenia (SZ), but
the cell type-specificity of DNA methylation makes population-based epigenetic studies of …

Cell-cell communication involves a large number of molecular signals that function as words
of a complex language whose grammar remains mostly unknown. Here, we describe an …

The substantial development of high-throughput biotechnologies has rendered large-scale
multi-omics datasets increasingly available. New challenges have emerged to process and …

Actinobacteria produce active secondary metabolite with medicinal properties, such as
antibacterial or anticancer. However, there are some reports about the difficulties in …

Motivated by an application in high-throughput genomics and metabolomics, we propose a
novel and fully data-driven approach for estimating large block structured sparse covariance …

Maize is currently the most productive cereal crop in the world (www. faostat. org). Maize can
form a symbiotic relationship with the Arbuscular Mycorrhizal Fungus (AMF), Rhizophagus …

Dans cette thèse nous nous intéressons au modèle linéaire général (modèle linéaire
multivarié) en grande dimension. Nous proposons un nouvel estimateur parcimonieux des …