We are developing a series of thiolesters that produce an immediate and sustained reversal
of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without …

L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a
variety of pharmacological effects. The purpose of this study was to determine the effects of L …

Carbonyl stress occurs when reactive carbonyl compounds (RCC), such as reducing sugars,
dicarbonyls etc., accumulate in the organism. The interaction of RCC carbonyl groups with …

A new method for investigating the mechanisms of nitric oxide release from NO donors
under oxidative and reductive conditions is presented. Based on the fragmentation of N …

The Maillard reaction is the key process in protein modification during pathologies
connected with carbonyl stress. It was shown in system modeling that Maillard reaction …

Photochemical release of nitric oxide (NO) from the S‐nitroso derivatives of glutathione, L‐
cysteine, N‐acetyl‐L‐cysteine, L‐cysteinemethylester, D, L‐penicillamine, N‐acetyl‐D, L …

S-nitrosothiol (RSNO) solutions represent a valuable source of nitric oxide and could be
used as topical vasodilators, but their fast decomposition rate poses a serious obstacle to …

We studied the involvement of O2, pH and low molecular thiols in H2S-induced
decomposition of S-nitrosoglutathione (GSNO). The GSNO decomposition–• NO release …

Quinones are one of the largest classes of antitumor agents approved for clinical use, and
several antitumor quinones are in various stages of clinical and preclinical development …

Sonolysis at 75kHz of argon-and air-saturated aqueous solutions at pH 7.4 containing s-
nitrosogluthathione (GSNO) enhances the production rate of nitric oxide (NO). The …