Human immunodeficiency virus (HIV) proteins in neuropathogenesis of HIV dementia
A Nath - The Journal of infectious diseases, 2002 - academic.oup.com
Human immunodeficiency virus (HIV) infection of the nervous system is unique when
compared with other viral encephalitides. Neuronal cell loss occurs in the absence of …
compared with other viral encephalitides. Neuronal cell loss occurs in the absence of …
Functions of Tat: the versatile protein of human immunodeficiency virus type 1
B Romani, S Engelbrecht… - Journal of general …, 2010 - microbiologyresearch.org
Human immunodeficiency virus type 1 (HIV-1) Tat is a multifunctional protein that contributes
to several pathological symptoms of HIV-1 infection as well as playing a critical role in virus …
to several pathological symptoms of HIV-1 infection as well as playing a critical role in virus …
HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress
II Kruman, A Nath, MP Mattson - Experimental neurology, 1998 - Elsevier
Patients infected with HIV-1 often exhibit cognitive deficits that are related to progressive
neuronal degeneration and cell death. The protein Tat, which is released from HIV-1 …
neuronal degeneration and cell death. The protein Tat, which is released from HIV-1 …
Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes: a hit and run phenomenon
The pathological correlates of dementia due to human immunodeficiency virus (HIV)
infection are glial cell activation and cytokine dysregulation. These findings occur in the …
infection are glial cell activation and cytokine dysregulation. These findings occur in the …
Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis
R Brack-Werner - Aids, 1999 - journals.lww.com
HIV can invade cells of the central nervous system (CNS) and cause progressive combined
cognitive and motor impairment in infected individuals. The cellular basis and mechanisms …
cognitive and motor impairment in infected individuals. The cellular basis and mechanisms …
HIV‐1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity
Toxic effects of HIV‐1 proteins contribute to altered function and decreased survival of select
populations of neurons in HIV‐1‐infected brain. One such HIV‐1 protein, Tat, can activate …
populations of neurons in HIV‐1‐infected brain. One such HIV‐1 protein, Tat, can activate …
Cell death in HIV dementia
Many patients infected with human immunodeficiency virus type-1 (HIV-1) suffer cognitive
impairment ranging from mild to severe (HIV dementia), which may result from neuronal …
impairment ranging from mild to severe (HIV dementia), which may result from neuronal …
Detection of the human immunodeficiency virus regulatory protein tat in CNS tissues
L Hudson, J Liu, A Nath, M Jones… - Journal of …, 2000 - Taylor & Francis
Neuropathologically, human immunodeficiency virus (HIV) is associated with a range of
inflammatory disorders, extensive cortical neuronal loss, and dendritic and synaptic …
inflammatory disorders, extensive cortical neuronal loss, and dendritic and synaptic …
[HTML][HTML] HIV tat and neurotoxicity
JE King, EA Eugenin, CM Buckner, JW Berman - Microbes and infection, 2006 - Elsevier
HIV tat is the transactivator of HIV-1, supporting efficient viral replication by stabilizing the
transcription of viral genes. Tat can be released from HIV-infected cells and alter several …
transcription of viral genes. Tat can be released from HIV-infected cells and alter several …
Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum
AK Bansal, CF Mactutus, A Nath, W Maragos… - Brain research, 2000 - Elsevier
HIV-associated dementia complex is a serious disabling disease characterized by cognitive,
behavioral and motor dysfunction. Basal ganglia involvement in HIV-1 infection may be …
behavioral and motor dysfunction. Basal ganglia involvement in HIV-1 infection may be …