The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia
As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle …
Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
The incretin hormone GLP‐1 and mechanisms underlying its secretion: 肠促胰岛素激素GLP‐1 及其潜在的分泌机制
L Tian, T Jin - Journal of diabetes, 2016 - Wiley Online Library
摘要胰高血糖素样肽‐1 (Glucagon‐like peptide‐1, GLP‐1) 是一种细胞类型特异性的胰高血糖
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
素原翻译后产物. 它是由胰高血糖素原基因所编码的, 在激素, 神经元以及营养的刺激下主要由肠 …
The redox role of G6PD in cell growth, cell death, and cancer
HC Yang, YH Wu, WC Yen, HY Liu, TL Hwang, A Stern… - Cells, 2019 - mdpi.com
The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …
Mechanisms by which skeletal muscle myokines ameliorate insulin resistance
R Balakrishnan, DC Thurmond - International journal of molecular …, 2022 - mdpi.com
The skeletal muscle is the largest organ in the body and secretes circulating factors,
including myokines, which are involved in various cellular signaling processes. Skeletal …
including myokines, which are involved in various cellular signaling processes. Skeletal …
P21 activated kinases: structure, regulation, and functions
CK Rane, A Minden - Small GTPases, 2014 - Taylor & Francis
The p21 activated kinases (Paks) are well known effector proteins for the Rho GTPases
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …
Cdc42 and Rac. The Paks contain 6 members, which fall into 2 families of proteins. The first …
Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …
Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation
A Klip, Y Sun, TT Chiu, KP Foley - American Journal of …, 2014 - journals.physiology.org
Skeletal muscle is the major tissue disposing of dietary glucose, a function regulated by
insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma …
insulin-elicited signals that impart mobilization of GLUT4 glucose transporters to the plasma …
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells
MA Kalwat, DC Thurmond - Experimental & molecular medicine, 2013 - nature.com
The maintenance of whole-body glucose homeostasis is critical for survival, and is
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …
controlled by the coordination of multiple organs and endocrine systems. Pancreatic islet β …
Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
In skeletal muscle, the actin cytoskeleton-regulating GTPase, Rac1, is necessary for insulin-
dependent GLUT4 translocation. Muscle contraction increases glucose transport and …
dependent GLUT4 translocation. Muscle contraction increases glucose transport and …