Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Covering: up to July 2015 Nonribosomal peptides are amongst the most widespread and
structurally diverse secondary metabolites in nature with many possessing bioactivity that …

Calcium-dependent antibiotics (CDA) are cyclic lipopeptides assembled by nonribosomal
peptide synthetase (NRPS) enzymes. Active site modification of the 3-methyl glutamate …

Covering: 2005 to 2012 Natural product analogue generation is important, providing tools
for chemical biology, enabling structure activity relationship determination and insight into …

Abstract Nicht‐ribosomale Peptidsynthetasen (NRPSs) sind große Multienzymmaschinerien,
die zahlreiche Peptide mit enormer struktureller und funktionaler Diversität erzeugen. Unter …

Pacidamycins, mureidomycins and napsamycins are structurally related uridyl peptide
antibiotics that inhibit translocase I, an as yet clinically unexploited target. This potentially …

Highlights•Nonribosomal peptides (NRPs) and polyketides (PKs) are important
pharmaceuticals.•Heterologous production of some NRPs and PKs has been achieved in …

The salinosporamides are potent proteasome inhibitors among which the parent marine-
derived natural product salinosporamide A (marizomib; NPI-0052; 1) is currently in clinical …

Incorporation of fluorine into an organic compound can favourably alter its physicochemical
properties with respect to biological activity, stability and lipophilicity. Accordingly, this …

A convergent synthesis via the late-stage serine ligation of naturally occurring calcium-
dependent antibiotic CDA3a and its analogues has been developed, which allowed us to …