The senses of proprioception, touch, hearing, and blood pressure on mechanosensitive ion
channels that transduce mechanical stimuli with high sensitivity and speed. This conversion …

Mechanosensitive ion channels mediate the neuronal sensation of mechanical signals such
as sound, touch, and pain. Recent studies point to a function of these channel proteins in …

In multicellular lives, the differentiation of stem cells and progenitor cells is often
accompanied by a transition from glycolysis to mitochondrial oxidative phosphorylation …

Gene therapy for genetic hearing loss is an emerging therapeutic modality for hearing
restoration. However, the approach has not yet been translated into clinical application. To …

Studies by His from 1868 to 1904 delineated the critical role of the dorsal roof plate in the
development of the hindbrain choroid plexus, and of the rhombic lips in the development of …

Background TMC1, which encodes transmembrane channel-like protein 1, forms the
mechanoelectrical transduction (MET) channel in auditory hair cells, necessary for auditory …

After the transition to life on land, tympanic middle ears emerged separately in different
groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way …

Most of Transmembrane protein 16 (TMEM16) family members function as either a Ca 2+-
activated Cl-channel (CaCC) or phospholipid scramblase (CaPLSase) and play diverse …

The auditory system detects and decodes sound pressure information. At the periphery,
mechanosensory hair cells detect and transmit sound information to auditory neurons …

Mechanosensing is a key feature through which organisms can receive inputs from the
environment and convert them into specific functional and behavioral outputs …