Remdesivir against COVID-19 and other viral diseases
JJ Malin, I Suárez, V Priesner… - Clinical microbiology …, 2020 - Am Soc Microbiol
Patients and physicians worldwide are facing tremendous health care hazards that are
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …
caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS …
RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
L Tian, T Qiang, C Liang, X Ren, M Jia, J Zhang… - European journal of …, 2021 - Elsevier
The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …
genomes that enable the infection to persist despite challenges presented by host cells …
Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease
ML Agostini, EL Andres, AC Sims, RL Graham… - MBio, 2018 - Am Soc Microbiol
Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved
therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated …
therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated …
Next generation of fluorine-containing pharmaceuticals, compounds currently in phase II–III clinical trials of major pharmaceutical companies: new structural trends …
Y Zhou, J Wang, Z Gu, S Wang, W Zhu… - Chemical …, 2016 - ACS Publications
Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …
interconnected research fields. These include the development of new materials with a …
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and …
D Siegel, HC Hui, E Doerffler, MO Clarke, K Chun… - 2017 - ACS Publications
The recent Ebola virus (EBOV) outbreak in West Africa was the largest recorded in history
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …
with over 28,000 cases, resulting in> 11,000 deaths including> 500 healthcare workers. A …
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the
number of cases and fatalities, geographic distribution, and number of nations affected …
number of cases and fatalities, geographic distribution, and number of nations affected …
The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold
MK Yates, KL Seley-Radtke - Antiviral research, 2019 - Elsevier
This is the second of two invited articles reviewing the development of nucleoside analogue
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …
antiviral drugs, written for a target audience of virologists and other non-chemists, as well as …
Remdesivir metabolite GS-441524 effectively inhibits SARS-CoV-2 infection in mouse models
Y Li, L Cao, G Li, F Cong, Y Li, J Sun… - Journal of medicinal …, 2021 - ACS Publications
The outbreak of coronavirus disease 2019 (COVID-19) has resulted in a global pandemic
due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C
EJ Gane, CA Stedman, RH Hyland… - … England Journal of …, 2013 - Mass Medical Soc
Background The standard treatment for hepatitis C virus (HCV) infection is interferon, which
is administered subcutaneously and can have troublesome side effects. We evaluated …
is administered subcutaneously and can have troublesome side effects. We evaluated …
Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective
treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable …
treatment of this disease. The HCV NS5B polymerase has been demonstrated to be a viable …