Alpha-ketoglutarate (AKG) is an intermediate in the Krebs cycle involved in various
metabolic and cellular pathways. As an antioxidant, AKG interferes in nitrogen and ammonia …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

The efficacy of chimeric antigen receptor (CAR) T cell therapy is hampered by relapse in
hematologic malignancies and by hyporesponsiveness in solid tumors. Long-lived memory …

The presence of emerging contaminants (ECs) in aquatic systems and, particularly, in
wastewater (WW) has become a major concern over the past years. Among these …

Increasing evidence indicates the involvement of myocardial oxidative injury and
mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate …

Background: Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs
(nuclear receptors) have been increasingly recognized as important regulators of cell …

Macrophages are multifunctional immune cells whose functions depend on polarizable
phenotypes and the microenvironment. Macrophages have two phenotypes, including the …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Disrupted biological function, manifesting through the hallmarks of aging, poses one of the
largest threats to healthspan and risk of disease development, such as metabolic disorders …

In swine production, stress is a common encounter that leads to serious bacterial infection
and adverse effects on growth performance. Though antibiotics have been frequently used …