Generic acquisition protocol for quantitative MRI of the spinal cord

J Cohen-Adad, E Alonso-Ortiz, M Abramovic… - Nature protocols, 2021 - nature.com
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges,
including a lack of standardized imaging protocols. Here we present a prospectively …

Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury

VA Dietz, N Roberts, K Knox, S Moore… - Frontiers in cellular …, 2022 - frontiersin.org
Through many decades of preclinical research, great progress has been achieved in
understanding the complex nature of spinal cord injury (SCI). Preclinical research efforts …

A randomized controlled trial of local delivery of a rho inhibitor (VX-210) in patients with acute traumatic cervical spinal cord injury

MG Fehlings, Y Chen, B Aarabi, F Ahmad… - Journal of …, 2021 - liebertpub.com
Acute traumatic spinal cord injury (SCI) can result in severe, lifelong neurological deficits.
After SCI, Rho activation contributes to collapse of axonal growth cones, failure of axonal …

[HTML][HTML] Cortico-spinal imaging to study pain

A Tinnermann, C Büchel, J Cohen-Adad - NeuroImage, 2021 - Elsevier
Functional magnetic resonance imaging of the brain has helped to reveal mechanisms of
pain perception in health and disease. Recently, imaging approaches have been developed …

Tracking white and gray matter degeneration along the spinal cord axis in degenerative cervical myelopathy

K Vallotton, G David, M Hupp, N Pfender… - Journal of …, 2021 - liebertpub.com
This study aims to determine tissue-specific neurodegeneration across the spinal cord in
patients with mild-moderate degenerative cervical myelopathy (DCM). Twenty-four mild …

Transplantation of chemical compound-induced cells from human fibroblasts improves locomotor recovery in a spinal cord injury rat model

T Kurahashi, C Nishime, E Nishinaka… - International Journal of …, 2023 - mdpi.com
The development of regenerative medicine using cell therapy is eagerly awaited for
diseases such as spinal cord injury (SCI), for which there has been no radical cure. We …

Neuroinflammation in the evolution of motor function in stroke and trauma patients: treatment and potential biomarkers

A Larrea, A Elexpe, E Díez-Martín, M Torrecilla… - Current Issues in …, 2023 - mdpi.com
Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal
cord injury, intervening in their pathophysiology: expansion, progression, and resolution …

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

HD Wang, ZJ Wei, JJ Li, SQ Feng - Neural Regeneration …, 2022 - journals.lww.com
Recent studies in patients with spinal cord injuries (SCIs) have confirmed the diagnostic
potential of biofluid-based biomarkers, as a topic of increasing interest in relation to SCI …

Improving diagnostic workup following traumatic spinal cord injury: advances in biomarkers

S Schading, TM Emmenegger, P Freund - Current neurology and …, 2021 - Springer
Abstract Purpose of Review Traumatic spinal cord injury (SCI) is a life-changing event with
drastic implications for patients due to sensorimotor impairment and autonomous …

Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system

MJ Mulcahey, LAT Jones, F Rockhold, R Rupp… - Spinal Cord, 2020 - nature.com
Abstract Study design Narrative review. Purpose To provide an overview of adaptive trial
designs, and describe how adaptive methods can address persistent challenges …