Background In recent years, disease treatment has evolved strategies that require increase
in pharmaceutical agent's efficacy and selectivity while decreasing their toxicity in normal …

Immunotherapy has emerged as a major therapeutic modality in oncology. Currently,
however, the majority of patients with cancer do not derive benefit from these treatments …

Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

Angiogenesis is the process of formation of new blood vessels from existing ones. Vessels
serve the purpose of providing oxygen, nutrients and removal of waste from the cells. The …

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

Introduction: Optimal management of recurrent ovarian cancer (ROC) remains an area of
uncertainty. An estimated 85% of patients with epithelial ovarian cancer who achieve a full …

Pericytes (PCs), known as mural cells, play an important blood vessel (BV) supporting role
in regulating vascular stabilization, permeability and blood flow in microcirculation as well as …

Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and
promotes inflammation, fibrosis, and progression to hepatocellular carcinoma (HCC) …

The treatment of malignancies has undergone dramatic changes in the past few decades.
Advances in drug delivery techniques and nanotechnology have allowed for new …

Background Antiangiogenic therapy has known activity in ovarian cancer. The investigator-
initiated randomised phase 2 TRIAS trial assessed the multi-kinase inhibitor sorafenib …