[HTML][HTML] Loss of fiber cell communication may contribute to the development of cataracts of many different etiologies

EC Beyer, RT Mathias, VM Berthoud - Frontiers in Physiology, 2022 - frontiersin.org
The lens is an avascular organ that is supported by an internal circulation of water and
solutes. This circulation is driven by ion pumps, channels and transporters in epithelial cells …

[HTML][HTML] Roles of eph-ephrin signaling in the eye lens cataractogenesis, biomechanics, and homeostasis

S Murugan, C Cheng - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The eye lens is responsible for fine focusing of light onto the retina, and its function relies on
tissue transparency and biomechanical properties. Recent studies have demonstrated the …

[HTML][HTML] Methodologies to unlock the molecular expression and cellular structure of ocular lens epithelial cells

J Parreno, G Emin, MP Vu, JT Clark, S Aryal… - Frontiers in Cell and …, 2022 - frontiersin.org
The transparent ocular lens in the anterior chamber of the eye is responsible for fine
focusing of light onto the retina. The lens is entirely cellular with bulk of the tissue composed …

[HTML][HTML] Mapping the universe of Eph receptor and ephrin ligand transcripts in epithelial and fiber cells of the eye lens

MP Vu, C Cheng - Cells, 2022 - mdpi.com
The eye lens is a transparent, ellipsoid organ in the anterior chamber of the eye that is
required for fine focusing of light onto the retina to transmit a clear image. Cataracts, defined …

Disease‐related non‐muscle myosin IIA D1424N rod domain mutation, but not R702C motor domain mutation, disrupts mouse ocular lens fiber cell alignment and …

ST Islam, S Cheheltani, C Cheng, VM Fowler - Cytoskeleton, 2024 - Wiley Online Library
The mouse ocular lens is an excellent vertebrate model system for studying hexagonal cell
packing and shape changes during tissue morphogenesis and differentiation. The lens is …

Preparation and immunofluorescence staining of bundles and single fiber cells from the cortex and nucleus of the eye lens

MP Vu, C Cheng - JoVE (Journal of Visualized Experiments), 2023 - jove.com
The lens is a transparent and ellipsoid organ in the anterior chamber of the eye that changes
shape to finely focus light onto the retina to form a clear image. The bulk of this tissue …

Spatial-Temporal Comparison of Eph/Ephrin Gene Expression in Ocular Lenses from Aging and Knockout Mice

PN Huynh, C Cheng - Frontiers in Ophthalmology, 2024 - frontiersin.org
Cataracts, defined as any opacity in the transparent ocular lens, remain the leading cause of
blindness and visual impairment in the world; however, the etiology of this pathology is not …

Author Spotlight: Advancing Lens Biomechanics Research Through a Novel Protocol for Imaging Complex Interdigitations and Protein Staining

MP Vu, C Cheng - JoVE (Journal of Visualized Experiments), 2023 - jove.com
The lens is a transparent and ellipsoid organ in the anterior chamber of the eye that changes
shape to finely focus light onto the retina to form a clear image. The bulk of this tissue …

[PDF][PDF] Mapping the Universe of Eph Receptor and Ephrin Ligand Transcripts in Epithelial and Fiber Cells of the Eye Lens. Cells 2022, 11, 3291

MP Vu, C Cheng - 2022 - pdfs.semanticscholar.org
The eye lens is a transparent, ellipsoid organ in the anterior chamber of the eye that is
required for fine focusing of light onto the retina to transmit a clear image. Cataracts, defined …