BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Genetics of Familial Hypercholesterolemia (FH) is ascribable to pathogenic variants in
genes encoding proteins leading to an impaired LDL uptake by the LDL receptor (LDLR) …

Comprehensively mapping the genetic basis of human disease across diverse individuals is
a long-standing goal for the field of human genetics,,–. The All of Us Research Program is a …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

Abstract Individuals with South Asian ancestry have a higher risk of heart disease than other
groups but have been largely excluded from genetic research. Using data from 22,000 …

Aims To assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors
in the type 2 diabetes mellitus (T2DM) population. Methods This cross‐sectional study …

Paragraph Whole-genome sequencing (WGS) provides a comprehensive view of the
genome, enabling detection of coding and non-coding genetic variation, and surveying …

The role of rare non-coding variation in complex human phenotypes is still largely unknown.
To elucidate the impact of rare variants in regulatory elements, we performed a whole …

Recently, large scale genomic projects such as All of Us and the UK Biobank have
introduced a new research paradigm where data are stored centrally in cloud-based Trusted …

Long non-coding RNAs (lncRNAs) are known to perform important regulatory functions in
lipid metabolism. Large-scale whole-genome sequencing (WGS) studies and new statistical …