Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

In the early 1980s, while using purified glycosyltransferases to probe glycan structures on
surfaces of living cells in the murine immune system, we discovered a novel form of …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic
nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to …

The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-
acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O …

O-GlcNAcylation is the covalent attachment of β-DN-acetylglucosamine (GlcNAc) sugars to
serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in …

The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis
and maintaining cellular redox homoeostasis in rapidly proliferating cells. Upregulation of …