Abstract Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and
its phosphorylation of its diverse substrates has major influences on many areas of …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Glycogen synthase kinase-3 (GSK-3) is one of the few signaling molecules that regulate a
truly astonishing number of critical intracellular signaling pathways. It has been implicated in …

Abstract The Wnt‐Frizzled (Fzd) G‐protein‐coupled receptor system, involving 19 distinct
Wnt ligands and 10 Fzd receptors, plays key roles in the development and functioning of …

Background and Purpose: Hydrogen (H 2) has been shown to have a strong antioxidant
effect on preventing oxidative stress-related diseases. The goal of the present study is to …

Myocardial fibrosis is a pathological hallmark of cardiac dysfunction. Oncostatin M (OSM) is
a pleiotropic cytokine that can promote fibrosis in different organs after sustained exposure …

Wnt signaling encompasses multiple and complex signaling cascades and is involved in
many developmental processes such as tissue patterning, cell fate specification, and control …

Sustained β-adrenergic receptors (βAR) activation leads to cardiac hypertrophy and
prevents left ventricular (LV) atrophy during LV unloading. The immediate signaling …

Heart failure with preserved ejection fraction (HFpEF) represents a multifaceted syndrome
related to complex pathologic mechanisms. Sacubitril/valsartan (Sac/val) has demonstrated …

The GSK-3 family of serine/threonine kinases, which is comprised of two isoforms (α and β),
was initially identified as a negative regulator of glycogen synthase, the rate limiting enzyme …