Molecular mechanism of phase I and phase II drug‐metabolizing enzymes: implications for detoxification
T Iyanagi - International review of cytology, 2007 - Elsevier
Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …
Flavodoxins: sequence, folding, binding, function and beyond
J Sancho - Cellular and Molecular Life Sciences CMLS, 2006 - Springer
Flavodoxins are electron-transfer proteins involved in a variety of photosynthetic and non-
photosynthetic reactions in bacteria, whereas, in eukaryotes, a descendant of the flavodoxin …
photosynthetic reactions in bacteria, whereas, in eukaryotes, a descendant of the flavodoxin …
A set of BEST triple-resonance experiments for time-optimized protein resonance assignment
A series of sequential, intra-residue, and bi-directional BEST H–N–CA, H–N–CO, and H–N–
CB pulse sequences is presented that extends the BEST concept introduced recently for fast …
CB pulse sequences is presented that extends the BEST concept introduced recently for fast …
How superoxide reductases and flavodiiron proteins combat oxidative stress in anaerobes
Microbial anaerobes are exposed in the natural environment and in their hosts, even if
transiently, to fluctuating concentrations of oxygen and its derived reactive species, which …
transiently, to fluctuating concentrations of oxygen and its derived reactive species, which …
The dual function of flavodiiron proteins: oxygen and/or nitric oxide reductases
Flavodiiron proteins have emerged in the last two decades as a newly discovered family of
oxygen and/or nitric oxide reductases widespread in the three life domains, and present in …
oxygen and/or nitric oxide reductases widespread in the three life domains, and present in …
Solution structure of the C-terminal nucleoprotein–RNA binding domain of the vesicular stomatitis virus phosphoprotein
Beyond common features in their genome organization and replication mechanisms, the
evolutionary relationships among viruses of the Rhabdoviridae family are difficult to …
evolutionary relationships among viruses of the Rhabdoviridae family are difficult to …
Structural insights into the enzyme catalysis from comparison of three forms of dissimilatory sulphite reductase from Desulfovibrio gigas
YC Hsieh, MY Liu, VCC Wang, YL Chiang… - Molecular …, 2010 - Wiley Online Library
The crystal structures of two active forms of dissimilatory sulphite reductase (Dsr) from
Desulfovibrio gigas, Dsr‐I and Dsr‐II, are compared at 1.76 and 2.05 Å resolution …
Desulfovibrio gigas, Dsr‐I and Dsr‐II, are compared at 1.76 and 2.05 Å resolution …
Surface charge interactions of the FMN module govern catalysis by nitric-oxide synthase
The FMN module of nitric-oxide synthase (NOS) plays a pivotal role by transferring NADPH-
derived electrons to the enzyme heme for use in oxygen activation. The process may involve …
derived electrons to the enzyme heme for use in oxygen activation. The process may involve …
Accurate characterization of weak macromolecular interactions by titration of NMR residual dipolar couplings: application to the CD2AP SH3-C: ubiquitin complex
JL Ortega-Roldan, MR Jensen, B Brutscher… - Nucleic acids …, 2009 - academic.oup.com
The description of the interactome represents one of key challenges remaining for structural
biology. Physiologically important weak interactions, with dissociation constants above 100 …
biology. Physiologically important weak interactions, with dissociation constants above 100 …
Structure, dynamics, and redox reactivity of an all-purpose flavodoxin
The flavodoxin of Rhodopseudomonas palustris CGA009 (Rp9Fld) supplies highly reducing
equivalents to crucial enzymes such as hydrogenase, especially when the organism is iron …
equivalents to crucial enzymes such as hydrogenase, especially when the organism is iron …