Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Animal models are useful to elucidate the etiology and pathology of glaucoma and to
develop novel and more effective therapies for the disease. Because of the substantial …

Purpose.: We assessed the relationship among intraocular pressure (IOP), histology, and
retinal function changes in a mouse model of induced, chronic, mild ocular hypertension …

Objectives Glaucoma is characterized by progressive damage of the retinal ganglion cells
(RGCs), resulting in irreversible vision loss. Cannabinoids (CBs) ameliorate several factors …

This study investigated contributions from the retinal On and Off pathways, and the spiking
and nonspiking activity of neurons in those pathways to the pattern ERG of the mouse. Light …

Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this
paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects …

Introduction: Rodents have widely been used to represent glaucomatous changes both in
the presence and absence of elevated intraocular pressure (IOP) as they offer clear …

Purpose.: To investigate the influence of deficiency in superoxide dismutase (SOD) 1, a
major antioxidative enzyme, on retinal ganglion cells (RGCs). Methods.: In the SOD1 total …

Methods.: Anesthetized (isoflurane) Long-Evans rats underwent unilateral circumlimbal
suture implantation while the fellow eyes served as untreated controls (n= 15). A sham …

Purpose.: Immunization with glatiramer acetate (GA) alleviates the neuropathology
associated with glaucoma and Alzheimer's disease (AD) in rodent models. This research …