Temporal transitions in the postembryonic nervous system of the nematode Caenorhabditis elegans: Recent insights and open questions

H Sun, O Hobert - Seminars in cell & developmental biology, 2023 - Elsevier
After the generation, differentiation and integration into functional circuitry, post-mitotic
neurons continue to change certain phenotypic properties throughout postnatal juvenile …

Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm

SR Doyle, A Tracey, R Laing, N Holroyd… - Communications …, 2020 - nature.com
Haemonchus contortus is a globally distributed and economically important gastrointestinal
pathogen of small ruminants and has become a key nematode model for studying …

Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms

SF Goodwin, O Hobert - Annual Review of Cell and …, 2021 - annualreviews.org
Male and female brains display anatomical and functional differences. Such differences are
observed in species across the animal kingdom, including humans, but have been …

Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans

HS Sun, O Hobert - Nature, 2021 - nature.com
In most animals, the majority of the nervous system is generated and assembled into
neuronal circuits during embryonic development. However, during juvenile stages, nervous …

[HTML][HTML] Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression

DA Ryan, RM Miller, KH Lee, SJ Neal, KA Fagan… - Current Biology, 2014 - cell.com
Background Adaptive behavioral prioritization requires flexible outputs from fixed neural
circuits. In C. elegans, the prioritization of feeding versus mate searching depends on …

Possible stochastic sex determination in Bursaphelenchus nematodes

R Shinya, S Sun, M Dayi, IJ Tsai, A Miyama… - Nature …, 2022 - nature.com
Sex determination mechanisms evolve surprisingly rapidly, yet little is known in the large
nematode phylum other than for Caenorhabditis elegans, which relies on chromosomal XX …

Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior

MM Barr, LR García, DS Portman - Genetics, 2018 - academic.oup.com
As fundamental features of nearly all animal species, sexual dimorphisms and sex
differences have particular relevance for the development and function of the nervous …

Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

J Wexler, EK Delaney, X Belles, C Schal… - Elife, 2019 - elifesciences.org
Insects are the only known animals in which sexual differentiation is controlled by sex-
specific splicing. The doublesex transcription factor produces distinct male and female …

GLP-1 Notch—LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1

J Chen, A Mohammad, N Pazdernik, H Huang… - PLoS …, 2020 - journals.plos.org
Stem cell systems are essential for the development and maintenance of polarized tissues.
Intercellular signaling pathways control stem cell systems, where niche cells signal stem …

The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system

H Lawson, E Vuong, RM Miller, K Kiontke, DHA Fitch… - Elife, 2019 - elifesciences.org
Sexual maturation must occur on a controlled developmental schedule. In mammals,
Makorin3 (MKRN3) and the miRNA regulators LIN28A/B are key regulators of this process …