DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?
CB Nemeroff - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …
associated with high levels of morbidity and mortality. Patients with major depression are …
Chronic stress-induced depression and anxiety priming modulated by gut-brain-axis immunity
Chronic stress manifests as depressive-and anxiety-like behavior while recurrent stress
elicits disproportionate behavioral impairments linked to stress-induced immunological …
elicits disproportionate behavioral impairments linked to stress-induced immunological …
Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression
C Böttcher, C Fernández-Zapata, GJL Snijders… - Translational …, 2020 - nature.com
Stress-induced disturbances of brain homeostasis and neuroinflammation have been
implicated in the pathophysiology of mood disorders. In major depressive disorder (MDD) …
implicated in the pathophysiology of mood disorders. In major depressive disorder (MDD) …
An integrative study of five biological clocks in somatic and mental health
Biological clocks have been developed at different molecular levels and were found to be
more advanced in the presence of somatic illness and mental disorders. However, it is …
more advanced in the presence of somatic illness and mental disorders. However, it is …
Epigenetic prediction of major depressive disorder
Variation in DNA methylation (DNAm) is associated with lifestyle factors such as smoking
and body mass index (BMI) but there has been little research exploring its ability to identify …
and body mass index (BMI) but there has been little research exploring its ability to identify …
Epigenetic aberrations in major psychiatric diseases related to diet and gut microbiome alterations
S Nohesara, HM Abdolmaleky, S Thiagalingam - Genes, 2023 - mdpi.com
Nutrition and metabolism modify epigenetic signatures like histone acetylation and DNA
methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) …
methylation. Histone acetylation and DNA methylation in the central nervous system (CNS) …
Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities
Background Epigenetic processes are fast emerging as a promising molecular system in the
search for both biomarkers and mechanisms underlying human health and disease risk …
search for both biomarkers and mechanisms underlying human health and disease risk …
The separation distress hypothesis of depression–an update and systematic review
DF Watt - Neuropsychoanalysis, 2023 - Taylor & Francis
The separation distress hypothesis of depression, formulated in 2009, offered an affective
neuroscience perspective on our most common and costly mental health condition, as an …
neuroscience perspective on our most common and costly mental health condition, as an …
DNA methylation as a mediator in the association between prenatal maternal stress and child mental health outcomes: Current state of knowledge
Background Prenatal maternal stress is increasingly recognized as a risk factor for offspring
mental health challenges. DNA methylation may be a mechanism, but few studies directly …
mental health challenges. DNA methylation may be a mechanism, but few studies directly …