[HTML][HTML] Intravitreal hydrogels for sustained release of therapeutic proteins

BC Ilochonwu, A Urtti, WE Hennink… - Journal of Controlled …, 2020 - Elsevier
This review highlights how hydrogel formulations can improve intravitreal protein delivery to
the posterior segment of the eye in order to increase therapeutic outcome and patient …

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

A Mandal, D Pal, V Agrahari, HM Trinh… - Advanced drug delivery …, 2018 - Elsevier
The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …

Principles of pharmacology in the eye

S Awwad, AHA Mohamed Ahmed… - British journal of …, 2017 - Wiley Online Library
The eye is a highly specialized organ that is subject to a huge range of pathology. Both local
and systemic disease may affect different anatomical regions of the eye. The least invasive …

Material solutions for delivery of CRISPR/Cas-based genome editing tools: Current status and future outlook

T Wan, D Niu, C Wu, FJ Xu, G Church, Y Ping - Materials Today, 2019 - Elsevier
Clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein
(CRISPR/Cas) system is an adaptable immune mechanism used by many bacteria to protect …

Bioinspired hydrogels for drug-eluting contact lenses

C Alvarez-Lorenzo, S Anguiano-Igea, A Varela-García… - Acta biomaterialia, 2019 - Elsevier
Efficient ocular drug delivery that can overcome the challenges of topical application has
been largely pursued. Contact lenses (CLs) may act as light-transparent cornea/sclera …

Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye–Part I–Barriers and determining factors in ocular delivery

E Sánchez-López, M Espina, S Doktorovova… - European Journal of …, 2017 - Elsevier
Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical
technology due to anatomical and physiological eye characteristics. The tissue barriers …

Injectable hydrogels for ophthalmic applications

K Wang, Z Han - Journal of Controlled Release, 2017 - Elsevier
The demand for effective eye therapies is driving the development of injectable hydrogels as
new medical devices for controlled delivery and filling purposes. This article introduces the …

Multifunctional Nanotherapeutics with Long-Acting Release against Macular Degeneration by Minimally Invasive Administration

W Chang, X Lv, J Zhu, JJ Shen, J Yao, Z Liu, Q Chen - ACS nano, 2024 - ACS Publications
Neovascular age-related macular degeneration (AMD), a leading cause of blindness,
requires frequent intravitreal injection of antivascular endothelial growth factor (anti-VEGF) …

Cellular regeneration strategies for macular degeneration: past, present and future

V Chichagova, D Hallam, J Collin, D Zerti, B Dorgau… - Eye, 2018 - nature.com
Despite considerable effort and significant therapeutic advances, age-related macular
degeneration (AMD) remains the commonest cause of blindness in the developed world …

Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives

Q Lyu, L Peng, X Hong, T Fan, J Li, Y Cui, H Zhang… - Biomaterials, 2021 - Elsevier
Smart nano-micro platforms have been extensively applied for diverse biomedical
applications, mostly focusing on cancer therapy. In comparison with conventional …