Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

Metformin has been a frontline therapy for type 2 diabetes (T2D) for many years. Its
effectiveness in T2D treatment is mostly attributed to its suppression of hepatic …

Metformin use is associated with reduced cancer mortality, but how metformin impacts
cancer outcomes is controversial. Although metformin can act on cells autonomously to …

Although cancer is still one of the most significant global challenges facing public health, the
world still lacks complementary approaches that would significantly enhance the efficacy of …

Geraniol is a monoterpenic alcohol with a pleasant rose-like aroma, known as an important
ingredient in many essential oils, and is used commercially as a fragrance compound in …

Silymarin contains a group of closely-related flavonolignan compounds including silibinin,
and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been …

Background It has been known for close to a century that, on average, tumors have a
metabolism that is different from those found in healthy tissues. Typically, tumors show a …