Assessment of cavitation intensity in accelerating syringes of spring-driven autoinjectors

J Eshraghi, JC Veilleux, G Shi, D Collins… - Pharmaceutical …, 2022 - Springer
Purpose Cavitation is an undesired phenomenon that may occur in certain types of
autoinjectors (AIs). Cavitation happens because of rapid changes of pressure in a liquid …

Modeling cavitation bubble dynamics in an autoinjector and its implications on drug molecules

Y Zhang, Z Dou, JC Veilleux, GH Shi, DS Collins… - International Journal of …, 2021 - Elsevier
The collapse of cavitation bubbles induced by abrupt acceleration of the syringe in an
autoinjector device can lead to protein aggregation. The details of bubble dynamics are …

[HTML][HTML] The air entrainment and hydrodynamic shear of the liquid slosh in syringes

J Eshraghi, Z Dou, JC Veilleux, G Shi, D Collins… - International Journal of …, 2022 - Elsevier
Understanding the interface motion and hydrodynamic shear induced by the liquid sloshing
during the insertion stage of an autoinjector can help improve drug product administration …

The interface motion and hydrodynamic shear of the liquid slosh in syringes

Y Zhang, D Han, Z Dou, JC Veilleux, GH Shi… - Pharmaceutical …, 2021 - Springer
Purpose Interface motion and hydrodynamic shear of the liquid slosh during the insertion of
syringes upon autoinjector activation may damage the protein drug molecules …

Numerical analysis of wave propagation across Solid–Fluid interface with Fluid–Structure interaction in circular tube

T Kojima, K Inaba - International Journal of Pressure Vessels and Piping, 2020 - Elsevier
Fluid–structure interaction (FSI) and wave propagation in engineering structures can cause
severe damage to piping systems or fluid machines, inducing serious accidents. In these …

[图书][B] Onset of cavitation in a dynamically loaded piston-cylinder

JC Kokkalis - 2023 - search.proquest.com
The pressure wave dynamics and associated cavitation in a water-filled cylinder are studied
experimentally. The use of a double and single-piston apparatus enables the system …

Dynamic Cavitation Inception by Wave Propagation Across Solid–Fluid Interface With Varying Solid Surface Wettability

T Kojima, K Inaba - Journal of Pressure Vessel …, 2023 - asmedigitalcollection.asme.org
Fluid–structure interaction (FSI) problems are important because they may induce serious
damage to structures. In some FSI problems, the interaction mechanism is strongly …

Methods and Analysis of Multiphase Flow and Interfacial Phenomena in Medical Devices

J Eshraghi - 2022 - search.proquest.com
Cavitation, liquid slosh, and splashes are ubiquitous in science and engineering. However,
these phenomena are not fully understood. Yet to date, we do not understand when or why …