Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagy is a major intracellular degradation system that derives its degradative abilities
from the lysosome. The most well-studied form of autophagy is macroautophagy, which …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane
autophagosome and their delivery to lysosomes for degradation. In multicellular organisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy/autophagy refers to the engulfment of cellular contents selected for
lysosomal degradation. The final step in autophagy is the fusion of autophagosome with the …

Endomembrane trafficking is essential for all eukaryotic cells. The best-characterized
membrane trafficking organelles include the endoplasmic reticulum (ER), Golgi apparatus …

The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …